Comparative nasal airflow with loratadine-pseudoephedrine and fluticasone nasal spray for allergic rhinitis

BackgroundAlthough it is known that oral antihistamine-pseudoephedrine combination tablets have a faster onset than intranasal corticosteroid sprays in the treatment of allergic rhinitis after first dose, magnitude change has not been measured comparative manner. Furthermore, sensation sprayed liquid nose may lead patients to mistakenly believe steroid work instantly.ObjectiveTo evaluate, numerically, nasal airflow changes provided by single dose loratadine-pseudoephedrine tablet (LP) and fluticasone propionate spray (FP) participants experiencing symptoms, including congestion.MethodsThis single-center, double-blinded, placebo-controlled, crossover study evaluated objective with documented sensitivity ragweed pollen. Participants were randomized receive 1 4 sequences, their peak inspiratory flow (PNIF) was span hours pollen exposure an environmental unit.ResultsAverage PNIF 31% LP course study, significantly greater placebo FP (12% 15%, respectively; P < .001). Nevertheless, did produce significant compared its placebo. At hour one post-dose, had clinically increase PNIF, whereas only yielded 8.6% (P Measurable improvements are associated opening passages, allowing congested breathe more freely.ConclusionA quickly .001) improved challenge unit. Comparatively, display this same benefit.Trial RegistrationClinicalTrials.gov Identifier: NCT03443843.